This work introduces a control strategy for hybrid piezoelectric-resonator-base (PR-based) DC-DC converters, specifically focusing on Dual-side Series/Parallel PR-based (DSPPR) converter. By delving into the out-of-phase behavior of piezoelectric resonator’s voltage, a finite-state-machine-based phase-locked loop (PLL) is established to track the optimal PR operation, maximizing efficiency performance. Moreover, incorporating adaptive synchronous rectification facilitates the effective operation of a hybrid PR-based converter while enhancing overall efficiency. In addition, the voltage regulation and loss minimization loop are established with PI compensations, enabling fully closed-loop operation with regulation capability. Also, the frontside switched capacitor balance loop is designed to clamp its capacitor voltage. Finally, a discrete prototype of dual-side series/parallel PR-based converter is built with a (20/0.2)mm PZT radial vibration mode PR to verify the proposed control strategy. Importantly, the proposed strategy can be applied to various reported PR-based converters.